头颈部癌症病史患者的晚期并发症和长期生存者的生活质量（>5 年）。
Late complications and long-term quality of life for survivors (>5 years) with history of head and neck cancer.
机构信息
Department of Pharmacy Practice, College of Pharmacy, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA.
出版信息
Head Neck. 2013 Jun;35(6):819-25. doi: 10.1002/hed.23035. Epub 2012 Jul 17.
BACKGROUND
Quality of life (QOL) outcomes become critical for survivors of head and neck cancer. Most QOL studies were based on <5-year outcomes and very few addressed >5-year outcomes. This study focused late complications and >5-year outcomes and also compared the 2 standard treatments.
METHODS
The long-term problems were identified through mail surveys. The 2 treatment arms were compared for differences.
RESULTS
Seventy-three of 234 possible survivors were identified as still living. Forty-seven returned responses were analyzed to determined problems and QOL. Fifty-three percent reported delayed complications which occurred after 5 years. When the 2 treatments were compared, no statistically significant differences were noted. The survivors in the chemoradiotherapy (CRT) group reported greater difficulties with swallowing, sticky saliva, feeding tube, and weight gain. The survivors in the surgery and postoperative radiation therapy (SRT) group reported more problems with trismus.
CONCLUSION
Some complications do not occur until after 5 years. The CRT group tended to have more problems.
背景
生活质量（QOL）结果对头颈癌幸存者至关重要。大多数 QOL 研究基于<5 年的结果，很少有研究涉及>5 年的结果。本研究重点关注晚期并发症和>5 年的结果，并比较了两种标准治疗方法。
方法
通过邮件调查确定长期问题。比较两个治疗组的差异。
结果
在 234 名可能的幸存者中，确定了 73 名仍在世的幸存者。对 47 份回复进行了分析，以确定问题和 QOL。53%的人报告了 5 年后发生的延迟并发症。当比较两种治疗方法时，没有发现统计学上的显著差异。接受放化疗（CRT）的幸存者在吞咽、粘痰、进食管和体重增加方面报告了更多困难。接受手术和术后放疗（SRT）的幸存者报告了更多的张口困难问题。
结论
一些并发症直到 5 年后才会发生。CRT 组的问题倾向于更多。
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