Division of Reproductive & Developmental Sciences, Oregon National Primate Research Center, Oregon Health & Science University, Beaverton, OR 97006, USA; Department of Obstetrics & Gynecology, Maternal Fetal Medicine, Oregon Health & Science University, Portland, OR 97239, USA.
Department of Obstetrics & Gynecology, Duke University Medical Center, Durham, NC 27710, USA.
Epigenomics. 2023 Apr;15(7):453-473. doi: 10.2217/epi-2023-0064. Epub 2023 Jun 7.
The rate of substance use is rising, especially among reproductive-age individuals. Emerging evidence suggests that paternal pre-conception and maternal prenatal substance use may alter offspring epigenetic regulation (changes to gene expression without modifying DNA) and outcomes later in life, including neurodevelopment and mental health. However, relatively little is known due to the complexities and limitations of existing studies, making causal interpretations challenging. This review examines the contributions and influence of parental substance use on the gametes and potential transmissibility to the offspring's epigenome as possible areas to target public health warnings and healthcare provider counseling of individuals or couples in the pre-conception and prenatal periods to ultimately mitigate short- and long-term offspring morbidity and mortality.
物质使用的比率正在上升，尤其是在生殖年龄的个体中。新出现的证据表明，父体孕前和母体产前的物质使用可能会改变后代的表观遗传调控（不改变 DNA 而改变基因表达）和以后生活中的结果，包括神经发育和心理健康。然而，由于现有研究的复杂性和局限性，这方面的知识相对较少，使得因果关系的解释具有挑战性。这篇综述考察了父母物质使用对配子的贡献和影响，以及潜在的可传递性对后代表观基因组的影响，这可能是针对公众健康警告和医疗保健提供者在孕前和孕期对个人或夫妇进行咨询的目标领域，最终减轻短期和长期后代发病率和死亡率。
