Department of Biochemistry and Organic Chemistry, Uppsala University, Box 576, 75123, Uppsala, Sweden.
Chemistry. 2012 Aug 20;18(34):10609-16. doi: 10.1002/chem.201200907. Epub 2012 Jul 13.
α,β-Unsaturated esters have been employed as substrates in iridium-catalyzed asymmetric hydrogenation. Full conversions and good to excellent enantioselectivities (up to 99 % ee) were obtained for a broad range of substrates with both aromatic- and aliphatic substituents on the prochiral carbon. The hydrogenated products are highly useful as building blocks in the synthesis of a variety of natural products and pharmaceuticals.
α,β-不饱和酯已被用作铱催化不对称氢化反应的底物。在具有芳香族和脂肪族取代基的手性碳原子上的广泛底物中，均获得了完全转化和优异的对映选择性（高达 99%ee）。氢化产物作为各种天然产物和药物合成中的构建块具有很高的应用价值。
