Noldy N E, Neiman J, el-Nesr B, Carlen P L
Neurology Program, Addiction Research Foundation, Toronto, Ont., Canada.
Neuropsychobiology. 1990;23(1):48-52. doi: 10.1159/000118715.
An auditory event-related potential paradigm was designed to objectively quantify the effects of drugs on the central nervous system (CNS). A series of tones was presented at three random interstimulus intervals (ISI). The amplitude of N1-P2 and the recovery of this complex across ISI appear to be rapid, reliable and sensitive measures of changes in brain function associated with drug intake. To illustrate, an acute dose of diazepam was administered orally to a small group of normal subjects. The amplitude of N1-P2 was reduced and the slope of recovery flattened, indicating a decrease in CNS excitability concomitantly with the established pharmacokinetics of the drug.
设计了一种听觉事件相关电位范式，以客观量化药物对中枢神经系统（CNS）的影响。在三个随机的刺激间隔（ISI）下呈现一系列音调。N1 - P2的振幅以及该复合体在ISI间的恢复情况似乎是与药物摄入相关的脑功能变化的快速、可靠且敏感的指标。举例来说，给一小群正常受试者口服一剂急性剂量的地西泮。N1 - P2的振幅降低，恢复斜率变平，表明中枢神经系统兴奋性降低，同时伴随着该药物既定的药代动力学情况。
