金黄色葡萄球菌铁依赖型溶血素的合成

Iron-dependent synthesis of hemolysins by Staphylococcus aureus.

作者信息

Leonov V V, Kosterina V V, Varnitsina V V, Timokhina T Kh, Kurlovich N A

机构信息

Department of Chemistry, Yugorsk State University, Khanty-Mansiysk, Russia.

出版信息

Bull Exp Biol Med. 2012 May;153(1):41-3. doi: 10.1007/s10517-012-1645-4.

DOI:10.1007/s10517-012-1645-4

PMID:22808489

Abstract

We studied the effect of Fe(2+) on hemolysin synthesis by Staphylococcus aureus. Hemolytic activity of staphylococci was shown to be iron-dependent. Addition of Fe(2+) to the nutrient medium induced the synthesis of α-hemolysin by staphylococci. Increasing the concentration of Fe(2+) was followed by an increase in hemolytic activity of staphylococci. Inducible synthesis of α-hemolysin probably serves as an important pathogenetic factor in the development of staphylococcal infection in patients with excessive iron accumulation in the body.

摘要

我们研究了Fe(2+)对金黄色葡萄球菌溶血素合成的影响。结果表明，葡萄球菌的溶血活性依赖于铁。向营养培养基中添加Fe(2+)可诱导葡萄球菌合成α-溶血素。随着Fe(2+)浓度的增加，葡萄球菌的溶血活性也随之增加。α-溶血素的诱导合成可能是体内铁蓄积过多患者发生葡萄球菌感染的一个重要致病因素。