Lopatina E V, Penniyaynen V A, Tsyrline V A
Department of Experimental Physiology and Pharmacology, V. A. Almazov Federal Heart, Blood, and Endocrinology Center, Federal Agency for High-Technological Medical Care, St. Petersburg, Russia.
Bull Exp Biol Med. 2012 May;153(1):48-50. doi: 10.1007/s10517-012-1639-2.
We studied the effect of norepinephrine and selective β(1)-adrenoceptor blockers on the growth of retinal tissue explants from 10-12-day-old chicken embryos in organotypic culture. The test drugs produced a dose-dependent effect on cell proliferation. Norepinephrine (10(-12) M) and atenolol (10(-4) M) are shown to significantly stimulate explant growth. Combined treatment with norepinephrine (10(-12) M) and atenolol (10(-4) M) results in cumulation of their stimulatory effects. The results suggest that the retina-stimulating effect of norepinephrine is based on its interactions with other types of adrenoceptors.
