Clement Y N, Ali S, Harripaulsingh S, Lacaille K, Mohammed O, Mohammed S, Ragbir T, Ramirez E, Tshiamo K
Pharmacology Unit, Department of Paraclinical Sciences, Faculty of Medical Sciences, The University of the West Indies, St Augustine, Trinidad and Tobago.
West Indian Med J. 2012 Jan;61(1):43-8.
To describe the drug prescribing pattern for hypertension at primary healthcare facilities throughout Trinidad.
A descriptive, cross-sectional survey was conducted at 22 primary healthcare facilities across Trinidad using a de novo, pilot-tested questionnaire during June to August 2006.
A total of 547 hypertensive patients were recruited into the study. There was a high prevalence of diabetes mellitus (57.6%). Information on the current drug prescribed was available for 442 patients (80.0%) and 26 of these patients (6.1%) were managed without drug intervention. On average, patients were prescribed 1.47 antihypertensive drugs. Angiotensin converting enzyme (ACE) inhibitors, particularly enalapril, were the most commonly prescribed class of antihypertensive drugs in 63.6% of patients. beta-blockers, thiazide diuretics and calcium channel blockers were prescribed in 29.2%, 25.8% and 12.0% of patients respectively.
There was significant use of ACE inhibitors, beta-blockers, thiazide diuretics and calcium channel blockers. Angiotensin converting enzyme inhibitors (as monotherapy or in combination with other drug classes) were more likely to be prescribed in diabetic hypertensive patients. Thiazide diuretics were not used as frequently as expected given the evidence which demonstrate similar efficacy with other classes of drugs and associated cost-saving. The observed prescribing pattern in the Trinidad public healthcare setting seems to point to an attempt to conform to recognized international and regional guidelines for the management of hypertension.
描述特立尼达岛各地基层医疗机构治疗高血压的用药模式。
2006年6月至8月期间,在特立尼达岛的22家基层医疗机构使用一份全新的、经过预试验的问卷进行了一项描述性横断面调查。
共有547名高血压患者纳入本研究。糖尿病患病率很高(57.6%)。442名患者(80.0%)有当前所开药物的信息,其中26名患者(6.1%)未经药物干预进行治疗。患者平均被开具1.47种抗高血压药物。血管紧张素转换酶(ACE)抑制剂,尤其是依那普利,是63.6%的患者中最常开具的抗高血压药物类别。β受体阻滞剂、噻嗪类利尿剂和钙通道阻滞剂分别在29.2%、25.8%和12.0%的患者中开具。
ACE抑制剂、β受体阻滞剂、噻嗪类利尿剂和钙通道阻滞剂的使用较为普遍。血管紧张素转换酶抑制剂(作为单一疗法或与其他药物类别联合使用)在糖尿病高血压患者中更有可能被开具。鉴于有证据表明噻嗪类利尿剂与其他药物类别疗效相似且能节省成本,但其使用频率未达预期。在特立尼达公共医疗环境中观察到的用药模式似乎表明试图遵循公认的国际和地区高血压管理指南。