Department of Chemistry and Molecular Biology, Medicinal Chemistry, University of Gothenburg, SE-41296 Göteborg, Sweden.
J Org Chem. 2012 Aug 17;77(16):7071-5. doi: 10.1021/jo300598d. Epub 2012 Aug 6.
This note describes a rapid and mild strategy for the loading of alcohols and anilines onto a polystyrene triphenylmethyl (trityl) resin. High loadings were obtained in a matter of minutes by treating resin-bound trityl chloride with triethyloxonium tetrafluoroborate followed by alcohols or anilines. Yields were comparable or better than known literature methods. Recycling of the recovered resin was also possible using the developed method.
本说明描述了一种快速而温和的将醇和苯胺载入聚苯乙烯三苯甲基(三苯甲基)树脂的策略。通过用三乙氧基氧鎓四氟硼酸盐处理树脂结合的三苯甲基氯,然后再用醇或苯胺处理,几分钟内即可获得高负载量。收率与已知文献方法相当或更好。使用所开发的方法,也可以回收再利用回收的树脂。