Bartels Christie M, Saucier Jessica M, Thorpe Carolyn T, Kind Amy J H, Pandhi Nancy, Hansen Karen E, Smith Maureen A
Arthritis Res Ther. 2012 Jul 18;14(4):R166. doi: 10.1186/ar3915.
Diabetes mellitus is a key predictor of mortality in rheumatoid arthritis (RA) patients. Both RA and diabetes increase the risk of cardiovascular disease (CVD), yet understanding of how comorbid RA impacts the receipt of guideline-based diabetes care is limited. The purpose of this study was to examine how the presence of RA affected hemoglobin A1C (A1c) and lipid measurement in older adults with diabetes.
Using a retrospective cohort approach, we identified beneficiaries ≥65 years old with diabetes from a 5% random national sample of 2004 to 2005 Medicare patients (N = 256,331), then examined whether these patients had comorbid RA and whether they received guideline recommended A1c and lipid testing in 2006. Multivariate logistic regression was used to examine the effect of RA on receiving guideline recommended testing, adjusting for baseline sociodemographics, comorbidities and health care utilization.
Two percent of diabetes patients had comorbid RA (N = 5,572). Diabetes patients with comorbid RA were more likely than those without RA to have baseline cardiovascular disease (such as 17% more congestive heart failure), diabetes-related complications including kidney disease (19% higher), lower extremity ulcers (77% higher) and peripheral vascular disease (32% higher). In adjusted models, diabetes patients with RA were less likely to receive recommended A1c testing (odds ratio (OR) 0.84, CI 0.80 to 0.89) than those without RA, but were slightly more likely to receive lipid testing (OR 1.08, CI 1.01 to 1.16).
In older adults with diabetes, the presence of comorbid RA predicted lower rates of A1c testing but slightly improved lipid testing. Future research should examine strategies to improve A1c testing in patients with diabetes and RA, in light of increased CVD and microvascular risks in patients with both conditions.
糖尿病是类风湿关节炎(RA)患者死亡率的关键预测指标。RA和糖尿病都会增加心血管疾病(CVD)的风险,但对于合并RA如何影响基于指南的糖尿病护理的接受情况,人们的了解有限。本研究的目的是探讨RA的存在如何影响老年糖尿病患者的糖化血红蛋白(A1c)和血脂检测。
采用回顾性队列研究方法,我们从2004年至2005年医疗保险患者的5%全国随机样本中识别出年龄≥65岁的糖尿病受益人(N = 256,331),然后检查这些患者是否合并RA,以及他们在2006年是否接受了指南推荐的A1c和血脂检测。使用多变量逻辑回归来检查RA对接受指南推荐检测的影响,并对基线社会人口统计学、合并症和医疗保健利用情况进行调整。
2%的糖尿病患者合并RA(N = 5,572)。合并RA的糖尿病患者比未患RA的患者更有可能患有基线心血管疾病(如充血性心力衰竭多17%)、包括肾病在内的糖尿病相关并发症(高19%)、下肢溃疡(高77%)和外周血管疾病(高32%)。在调整后的模型中,患有RA的糖尿病患者比未患RA的患者接受推荐的A1c检测的可能性更小(优势比(OR)为0.84,可信区间为0.80至0.89),但接受血脂检测的可能性略高(OR为1.08,可信区间为1.01至1.16)。
在老年糖尿病患者中,合并RA预示着A1c检测率较低,但血脂检测略有改善。鉴于同时患有这两种疾病的患者心血管疾病和微血管风险增加,未来的研究应探讨改善糖尿病和RA患者A1c检测的策略。