Department of Psychology (at Guy's), Institute of Psychiatry, King's College London, London, UK.
Climacteric. 2013 Apr;16(2):235-9. doi: 10.3109/13697137.2012.688078. Epub 2012 Jul 18.
Despite a large body of research on menopause, there is little definitive evidence of the impact of vasomotor symptoms on health-related quality of life (HrQoL). Therefore, this study describes the HrQoL of menopausal women with hot flushes and night sweats and examines predictors of HrQoL.
A total of 140 women reporting at least ten hot flushes/night sweats (vasomotor symptoms) a week for at least a month completed an assessment interview (including medical history, past and current physical and mental health and menopausal status) and questionnaires eliciting sociodemographic and help-seeking information, HrQoL and the Hot Flush Rating Scale.
Women with vasomotor symptoms reported somewhat reduced HrQoL compared to SF-36 US norms and a general sample of UK menopausal women; 53% reported comorbid physical illness and 66% had current psychosocial concerns; 77% had visited their doctor about menopausal symptoms; 28% were past and 3% current users of hormone therapy. Overall, poor HrQoL was associated with having problematic hot flushes, current psychosocial concerns, (younger) age, (higher) body mass index and poor general health.
This sample of relatively healthy mid-aged women with vasomotor symptoms reported reduced HrQoL compared to age-matched norms and a general sample of menopausal women. Problem rating, rather than frequency, of hot flushes was associated with reduced HrQoL, as were health and psychosocial factors.
尽管有大量关于绝经的研究，但关于血管舒缩症状对健康相关生活质量（HrQoL）的影响，几乎没有明确的证据。因此，本研究描述了有热潮和盗汗的绝经妇女的 HrQoL，并探讨了其 HrQoL 的预测因素。
共有 140 名女性每周至少有 10 次热潮/盗汗（血管舒缩症状），持续至少一个月，完成了评估访谈（包括病史、过去和现在的身心健康状况和绝经状态）以及问卷调查，以获取社会人口统计学和寻求帮助的信息、HrQoL 和热潮评分量表。
与 SF-36 美国标准和英国一般绝经女性相比，有血管舒缩症状的女性报告的 HrQoL 略有下降；53%的女性报告同时患有躯体疾病，66%的女性有当前的心理社会问题；77%的女性因绝经症状看过医生；28%的女性过去曾使用过激素治疗，3%的女性目前正在使用。总体而言，较差的 HrQoL 与存在问题的热潮、当前的心理社会问题、（更年轻）年龄、（更高）体重指数和较差的一般健康状况有关。
与年龄匹配的标准和一般绝经女性相比，本研究中相对健康的中年女性血管舒缩症状组报告的 HrQoL 降低。热潮的评分，而不是频率，与 HrQoL 的降低有关，健康和心理社会因素也是如此。
