McKay Orthopaedic Research Laboratory, Department of Orthopaedic Surgery, University of Pennsylvania, Philadelphia, Pennsylvania 19104-6081, USA.
Annu Rev Biomed Eng. 2012;14:47-71. doi: 10.1146/annurev-bioeng-071811-150122.
Injury and degeneration of tendon, the soft tissue that mechanically links muscle and bone, can cause substantial pain and loss of function. This review discusses the composition and function of healthy tendon and describes the structural, biological, and mechanical changes initiated during the process of tendon healing. Biochemical pathways activated during repair, experimental injury models, and parallels between tendon healing and tendon development are emphasized, and cutting-edge strategies for the enhancement of tendon healing are discussed.
肌腱损伤和退变，即连接肌肉和骨骼的软组织，可导致严重疼痛和功能丧失。本文讨论了健康肌腱的组成和功能，并描述了在肌腱愈合过程中引发的结构、生物和力学变化。本文强调了修复过程中激活的生化途径、实验性损伤模型以及肌腱愈合与肌腱发育之间的相似性，并讨论了增强肌腱愈合的最新策略。
