Heredia Sulbaran Angel Alberto, Gomez Pablo Alonso
Infanta Elena Hospital, Carretera Sevilla s/n, Huelva, 21080, Spain.
BMC Musculoskelet Disord. 2025 Jul 4;26(1):619. doi: 10.1186/s12891-025-08811-9.
BACKGROUND/OBJECTIVES: Hydrolyzed collagen (CHG) is an emerging infiltrative therapy for the treatment of osteoarthritis. The objective of this retrospective study was to compare its effectiveness with that of hyaluronic acid (HA) and platelet-rich plasma (PRP).
The Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) scores of 72 patients with Kellgren-Lawrence grade 1-4 osteoarthritis were recorded and analyzed over a 12-month follow-up period. Patients received either three CHG injections, a single HA injection, or three PRP injections and the results were compared. Of the participants, 23 were treated with CHG, 25 with HA, and 24 with PRP.
Treatment effectiveness was assessed at 3, 6, and 12 months. At the 12-month follow-up, the CHG group showed a 56% improvement in the WOMAC total score, compared to 22.5% for the HA group and 47% for the PRP group. Pain reduction was also greatest in the CHG group, with a 52% decrease at 12 months, versus 16% in the HA group (p < 0.05).
In this retrospective study, CHG demonstrated a more sustained therapeutic effect in terms of pain relief and functional improvement compared to HA and PRP over a one-year period. No side effects were observed in any of the treatment groups.
背景/目的：水解胶原蛋白（CHG）是一种新兴的用于治疗骨关节炎的浸润性疗法。本回顾性研究的目的是比较其与透明质酸（HA）和富血小板血浆（PRP）的疗效。
记录并分析了72例凯尔格伦-劳伦斯分级为1-4级骨关节炎患者在12个月随访期内的西安大略和麦克马斯特大学骨关节炎指数（WOMAC）评分。患者分别接受三次CHG注射、一次HA注射或三次PRP注射，并比较结果。参与者中，23例接受CHG治疗，25例接受HA治疗，24例接受PRP治疗。
在3个月、6个月和12个月时评估治疗效果。在12个月的随访中,CHG组的WOMAC总分改善了56%，而HA组为22.5%，PRP组为47%。CHG组的疼痛减轻也最为显著，12个月时疼痛减轻了52%，而HA组为16%（p<0.05）。
在本回顾性研究中，与HA和PRP相比，CHG在一年时间内的疼痛缓解和功能改善方面表现出更持久的治疗效果。在任何治疗组中均未观察到副作用。
