脓毒症中的维生素D：从基础科学到临床影响
Vitamin D in sepsis: from basic science to clinical impact.
作者信息
Kempker Jordan A, Tangpricha Vin, Ziegler Thomas R, Martin Greg S
出版信息
Crit Care. 2012 Jul 19;16(4):316. doi: 10.1186/cc11252.
Abstract
The growing basic and clinical investigations into the extraskeletal effects of vitamin D have revealed roles in the functioning of the immune system, generating interesting questions about this nutrient's connections to sepsis. This article briefly reviews the current science of the function of vitamin D in the immune system as well as the emerging clinical literature regarding its associations with respiratory infections, sepsis, and critical illness. Finally, we offer views on the potential future directions for research in the field by outlining potential relevant scenarios and outcomes.
摘要
对维生素D骨骼外作用的基础和临床研究不断增加，揭示了其在免疫系统功能中的作用，引发了关于这种营养素与败血症之间联系的有趣问题。本文简要回顾了维生素D在免疫系统中功能的当前科学研究，以及关于其与呼吸道感染、败血症和危重病关联的新兴临床文献。最后，我们通过概述潜在的相关情况和结果，对该领域未来的研究方向提出看法。
相似文献
1
Vitamin D in sepsis: from basic science to clinical impact.脓毒症中的维生素D：从基础科学到临床影响
Crit Care. 2012 Jul 19;16(4):316. doi: 10.1186/cc11252.
2
Vitamin D and sepsis: from associations to causal connections.维生素D与脓毒症：从关联到因果联系
Inflamm Allergy Drug Targets. 2013 Aug;12(4):246-52. doi: 10.2174/18715281113129990048.
3
An update on the association of vitamin D deficiency with common infectious diseases.维生素D缺乏与常见传染病关联的最新情况
Can J Physiol Pharmacol. 2015 May;93(5):363-8. doi: 10.1139/cjpp-2014-0352. Epub 2015 Jan 26.
4
Vitamin D in burn-injured patients.烧伤患者体内的维生素D
Burns. 2019 Feb;45(1):32-41. doi: 10.1016/j.burns.2018.04.015.
5
The role of vitamin D deficiency in sepsis and potential therapeutic implications.维生素 D 缺乏在脓毒症中的作用及潜在治疗意义。
J Infect. 2011 Nov;63(5):321-6. doi: 10.1016/j.jinf.2011.07.002. Epub 2011 Jul 13.
6
Vitamin D and child health: part 2 (extraskeletal and other aspects).维生素 D 与儿童健康：第 2 部分（骨骼外及其他方面）。
Arch Dis Child. 2013 May;98(5):368-72. doi: 10.1136/archdischild-2012-302585. Epub 2013 Mar 14.
7
Vitamin D metabolism and deficiency in critical illness.维生素 D 代谢与危重病中的缺乏。
Best Pract Res Clin Endocrinol Metab. 2011 Oct;25(5):769-81. doi: 10.1016/j.beem.2011.03.001.
8
[Role and mechanism of vitamin D in sepsis].[维生素D在脓毒症中的作用及机制]
Zhonghua Wei Zhong Bing Ji Jiu Yi Xue. 2019 Sep;31(9):1170-1173. doi: 10.3760/cma.j.issn.2095-4352.2019.09.024.
9
The vitamin D connection to pediatric infections and immune function.维生素 D 与儿科感染和免疫功能的关系。
Pediatr Res. 2009 May;65(5 Pt 2):106R-113R. doi: 10.1203/PDR.0b013e31819dba91.
10
Vitamin D and the critically ill patient.维生素 D 与危重症患者。
Curr Opin Clin Nutr Metab Care. 2012 Mar;15(2):188-93. doi: 10.1097/MCO.0b013e32834f0027.
引用本文的文献
1
Effects of different vitamins on individuals with septic shock: a Bayesian NMA of RCTs.不同维生素对感染性休克患者的影响：随机对照试验的贝叶斯网络Meta分析
Front Nutr. 2025 Aug 13;12:1566422. doi: 10.3389/fnut.2025.1566422. eCollection 2025.
2
The Role of Vitamin D and Vitamin D Receptor in Sepsis.维生素D及维生素D受体在脓毒症中的作用
Curr Issues Mol Biol. 2025 Jul 1;47(7):500. doi: 10.3390/cimb47070500.
3
1,25(OH)2D3 supplementation alleviates gut-vascular barrier disruption via inhibition of S100B/ADAM10 pathway.1,25(OH)2D3 补充通过抑制 S100B/ADAM10 通路缓解肠道-血管屏障破坏。
Tissue Barriers. 2024 Oct;12(4):2327776. doi: 10.1080/21688370.2024.2327776. Epub 2024 Mar 17.
4
A Comprehensive Review of the Immunomodulatory Effects of Vitamin D in Sepsis.维生素D在脓毒症中免疫调节作用的综合综述
Cureus. 2024 Feb 5;16(2):e53678. doi: 10.7759/cureus.53678. eCollection 2024 Feb.
5
Effect of vitamin D on clinical outcomes in patients with thermal injury.维生素 D 对热损伤患者临床结局的影响。
Int Wound J. 2024 Feb;21(2):e14641. doi: 10.1111/iwj.14641.
6
Acute Respiratory Distress Syndrome; A Review of Recent Updates and a Glance into the Future.急性呼吸窘迫综合征：近期进展回顾与未来展望
Diagnostics (Basel). 2023 Apr 24;13(9):1528. doi: 10.3390/diagnostics13091528.
7
Effects of vitamin D insufficiency on sepsis severity and risk of hospitalisation in emergency department patients: a cross-sectional study.维生素 D 不足对急诊科患者脓毒症严重程度和住院风险的影响：一项横断面研究。
BMJ Open. 2023 Jan 17;13(1):e064985. doi: 10.1136/bmjopen-2022-064985.
8
Bibliometric analysis of the global research status and trends of the association between Vitamin D and infections from 2001 to 2021.2001年至2021年维生素D与感染关联的全球研究现状及趋势的文献计量分析
Front Public Health. 2022 Aug 4;10:934106. doi: 10.3389/fpubh.2022.934106. eCollection 2022.
9
Correlation of Gut Microbiota, Vitamin D Status, and Pulmonary Function Tests in Children With Cystic Fibrosis.囊性纤维化患儿肠道微生物群、维生素D状态与肺功能测试的相关性
Front Nutr. 2022 Jun 9;9:884104. doi: 10.3389/fnut.2022.884104. eCollection 2022.
10
A Potential Role of Vitamin D on Platelet Leukocyte Aggregation and Pathological Events in Sepsis: An Updated Review.维生素D在脓毒症患者血小板白细胞聚集及病理过程中的潜在作用：最新综述
J Inflamm Res. 2021 Jul 30;14:3651-3664. doi: 10.2147/JIR.S321362. eCollection 2021.
本文引用的文献
1
Vitamin D and chronic lung disease: a review of molecular mechanisms and clinical studies.维生素 D 与慢性肺部疾病：分子机制与临床研究综述。
Adv Nutr. 2011 May;2(3):244-53. doi: 10.3945/an.111.000398. Epub 2011 Apr 30.
2
Vitamin D inhibits monocyte/macrophage proinflammatory cytokine production by targeting MAPK phosphatase-1.维生素 D 通过靶向 MAPK 磷酸酶-1 抑制单核细胞/巨噬细胞促炎细胞因子的产生。
J Immunol. 2012 Mar 1;188(5):2127-35. doi: 10.4049/jimmunol.1102412. Epub 2012 Feb 1.
3
Effects of vitamin D deficiency in critically ill surgical patients.危重症外科患者维生素 D 缺乏的影响。
Am J Surg. 2012 Mar;203(3):379-82; discussion 382. doi: 10.1016/j.amjsurg.2011.09.012. Epub 2011 Dec 28.
4
Vitamin D and the critically ill patient.维生素 D 与危重症患者。
Curr Opin Clin Nutr Metab Care. 2012 Mar;15(2):188-93. doi: 10.1097/MCO.0b013e32834f0027.
5
Serum 25-hydroxyvitamin D levels and all-cause and cardiovascular disease mortality among US adults with hypertension: the NHANES linked mortality study.血清 25-羟维生素 D 水平与美国高血压成年人全因和心血管疾病死亡率：NHANES 链接死亡率研究。
J Hypertens. 2012 Feb;30(2):284-9. doi: 10.1097/HJH.0b013e32834e1f0a.
6
Vitamin D deficiency is associated with mortality in the medical intensive care unit.维生素 D 缺乏与重症监护病房的死亡率有关。
Crit Care. 2011;15(6):R292. doi: 10.1186/cc10585. Epub 2011 Dec 10.
7
Low serum 25-hydroxyvitamin D at critical care initiation is associated with increased mortality.起始重症监护时血清 25-羟维生素 D 水平低与死亡率增加相关。
Crit Care Med. 2012 Jan;40(1):63-72. doi: 10.1097/CCM.0b013e31822d74f3.
8
Vitamin D deficiency in septic patients at ICU admission is not a mortality predictor.入住 ICU 的脓毒症患者维生素 D 缺乏并不是死亡的预测指标。
Minerva Anestesiol. 2011 Dec;77(12):1184-9. Epub 2011 Jun 30.
9
Vitamin D status and risk of cardiovascular events: lessons learned via systematic review and meta-analysis.维生素 D 状况与心血管事件风险：系统评价和荟萃分析得出的经验教训。
Cardiol Rev. 2011 Jul-Aug;19(4):192-201. doi: 10.1097/CRD.0b013e31821da9a5.
10
Evaluation, treatment, and prevention of vitamin D deficiency: an Endocrine Society clinical practice guideline.维生素 D 缺乏的评估、治疗和预防：内分泌学会临床实践指南。
J Clin Endocrinol Metab. 2011 Jul;96(7):1911-30. doi: 10.1210/jc.2011-0385. Epub 2011 Jun 6.
Zotero 插件