Department of Chemistry and Biochemistry, Institute of Biosciences, UNESP-University of State of São Paulo, Unesp Botucatu, SP, Brazil.
Food Chem Toxicol. 2012 Oct;50(10):3556-61. doi: 10.1016/j.fct.2012.07.009. Epub 2012 Jul 15.
We reported the effects of quercetin on metabolic and hormonal profile as well as serum antioxidant activities in a model of MSG (monosodium glutamate)-induced obesity. Rats were divided into 4 groups: MSG group, submitted to neonatal treatment with high doses of MSG, administrated subcutaneously during 10 days, from 2 day-old; control groups, which received the same volume of saline. After completing 30 day-old, these groups were subdivided into 4 groups: control and MSG groups treated and non-treated with quercetin at doses of 75 mg/kg body weight (i.p.) over 42 days. BW gain and food consumption were higher in MSG treated rats and quercetin significantly reduced BW by 25%. While MSG increased triacylglycerol, total cholesterol and fractions, and reduced HDL concentrations, administration of quercetin normalized HDL-cholesterol and reduced others lipids. Insulin, leptin, glucose and creatinine levels were raised in MSG-treated rats and reduced after quercetin treatment. Alanine transaminase, aspartate transaminase, lactate dehydrogenase and alkaline phosphatase activities were lower after MSG-quercetin combination compared to rats given only MSG. MSG-quercetin combination augmented total protein and urea levels as well as glutathione peroxidase and superoxide dismutase activities in contrast to MSG-treated animals. Quercetin normalized serum lipid and glucose profile and minimized the MSG-related toxic effects, which was associated to its antioxidant properties.
我们报告了槲皮素对代谢和激素谱以及血清抗氧化活性的影响，在 MSG（谷氨酸单钠）诱导的肥胖模型中。大鼠分为 4 组：MSG 组，接受新生期大剂量 MSG 处理，皮下注射 10 天，从 2 天大；对照组，给予相同体积的生理盐水。完成 30 天大后，这些组再分为 4 组：对照组和 MSG 组，用 75mg/kg 体重（ip）的槲皮素治疗和非治疗 42 天。MSG 处理的大鼠体重增加和食物消耗增加，而槲皮素可使体重降低 25%。虽然 MSG 增加了三酰甘油、总胆固醇和各部分，但降低了 HDL 浓度，但槲皮素可使 HDL 胆固醇正常化并降低其他脂质。MSG 处理的大鼠胰岛素、瘦素、葡萄糖和肌酐水平升高，而槲皮素治疗后降低。丙氨酸转氨酶、天冬氨酸转氨酶、乳酸脱氢酶和碱性磷酸酶活性在 MSG-槲皮素联合组中低于仅给予 MSG 的大鼠。与 MSG 处理的动物相比，MSG-槲皮素联合组增加了总蛋白和尿素水平以及谷胱甘肽过氧化物酶和超氧化物歧化酶活性。槲皮素使血清脂质和葡萄糖谱正常化，并最大限度地减少了与 MSG 相关的毒性作用，这与其抗氧化特性有关。
