School of Biosciences, Mahatma Gandhi University, Kottayam, Kerala 686560, India.
Toxicol Mech Methods. 2012 Oct;22(8):625-30. doi: 10.3109/15376516.2012.714008.
Chronic oral intake of high doses of monosodium glutamate (MSG) could be harmful to tissues and organs. Oxidative stress enhances membrane damage by lipid peroxidation and alterations of antioxidant enzymes, which affects the functional activity of organs. Antioxidant vitamins have the capacity to regulate the oxidative stress related functional and pathological processes.
In this study, the protective role of α-tocopherol against MSG-induced nephrotoxicity was analyzed.
MSG (4 g/kg) was given orally to female wistar rats for a period of 180 days. Renal function parameters (urea, uric acid, and creatinine), lipid peroxidation markers (malondialdehyde and conjugated dienes), antioxidant system (superoxide dismutase, catalase, glutathione peroxidase, glutathione transferase, and reduced glutathione), and histopathology were investigated. All tests were done in rats treated with MSG and at two different doses of α-tocopherol (100 and 200 mg/kg).
Oral exposure of MSG significantly increased renal function markers, lipid peroxidation byproducts, and altered antioxidant system. Moreover, the kidney showed congested glomeruli, tubular swelling, capillary congestion and microhemorrhages in stromal areas of the tubules. Co-administration of MSG and α-tocopherol (200 mg/kg) significantly reduced the oxidative damage compared with MSG-treated group and also restored the normal renal function.
The results indicated that oxidative stress was involved in MSG-induced functional and pathological changes in the kidney. α-tocopherol modulates the functional disorder and maintains the normal architecture of renal tissue by reducing oxidative stress.
The α-tocopherol may be a potent protective agent in combating MSG-induced renal toxicity.
长期口服大剂量的味精（MSG）可能对组织和器官有害。氧化应激通过脂质过氧化和抗氧化酶的改变增强膜损伤，从而影响器官的功能活性。抗氧化维生素有调节与氧化应激相关的功能和病理过程的能力。
本研究分析了 α-生育酚对 MSG 诱导的肾毒性的保护作用。
雌性 Wistar 大鼠口服 MSG（4 g/kg），持续 180 天。检测肾功能参数（尿素、尿酸和肌酐）、脂质过氧化标志物（丙二醛和共轭二烯）、抗氧化系统（超氧化物歧化酶、过氧化氢酶、谷胱甘肽过氧化物酶、谷胱甘肽转移酶和还原型谷胱甘肽）和组织病理学变化。所有测试均在接受 MSG 和两种不同剂量 α-生育酚（100 和 200 mg/kg）治疗的大鼠中进行。
MSG 的口服暴露显著增加了肾功能标志物、脂质过氧化产物，并改变了抗氧化系统。此外，肾脏显示肾小球充血、肾小管肿胀、毛细血管充血和肾小管间质区微出血。与 MSG 处理组相比，MSG 和 α-生育酚（200 mg/kg）联合给药显著降低了氧化损伤，并且还恢复了正常的肾功能。
结果表明，氧化应激参与了 MSG 诱导的肾脏功能和病理变化。α-生育酚通过减少氧化应激来调节功能障碍并维持肾脏组织的正常结构。
α-生育酚可能是对抗 MSG 诱导的肾毒性的有效保护剂。
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