Division of Neonatology, Department of Obstetrics and Gynecology, University Hospital Sveti Duh, School of Medicine, University of Zagreb, Zagreb, Croatia.
Semin Fetal Neonatal Med. 2012 Dec;17(6):324-9. doi: 10.1016/j.siny.2012.06.006. Epub 2012 Jul 17.
The human brain is very sensitive to environmental changes affecting its growth and development. Environmental changes influence neonatal behavior after birth, enabling continuity between prenatal and postnatal behavior, but postnatal adaptation could be considered as discontinuity. Thus there is the question of environmental discontinuity between intrauterine conditions characterized by existence of microgravity and extrauterine life with gravity as a developmental condition sine qua non. Four-dimensional ultrasound is currently being assessed as a functional prenatal screening test for detection of neurological impairment in utero. The Kurjak Antenatal Neurodevelopmental Test (KANET) combines the assessment of fetal behavior, general movements, and three out of four signs that have been postnatally considered as symptoms of possible neurodevelopmental impairment (neurological thumb, overlapping sutures and small head circumference). Although the KANET has been tested on normal and high-risk pregnancies, the significance of the test for detection and prevention of neurodevelopmental disability is still questionable.
人类大脑对外界环境的变化非常敏感，这些变化会影响大脑的生长和发育。环境变化会影响新生儿出生后的行为，使产前和产后的行为具有连续性，但这种连续性也可以被视为一种不连续性。因此，在以微重力为特征的宫内环境和以重力为必要发育条件的宫外生活之间，存在着环境不连续性的问题。目前，四维超声被评估为一种功能性产前筛查测试，用于检测宫内神经发育障碍。Kurjak 产前神经发育测试（KANET）结合了胎儿行为、一般运动以及出生后被认为可能存在神经发育障碍（神经拇指、重叠的颅骨缝和小头围）的四个体征中的三个的评估。尽管 KANET 已经在正常和高危妊娠中进行了测试，但该测试在检测和预防神经发育障碍方面的意义仍存在争议。
