Division of Biosurface Technology, Biomedical Technology Wing, Sree Chitra Tirunal Institute for Medical Science and Technology, Thiruvananthapuram 695012, Kerala, India.
Colloids Surf B Biointerfaces. 2013 Jan 1;101:196-204. doi: 10.1016/j.colsurfb.2012.06.027. Epub 2012 Jun 29.
The present study focuses on the development of a biocompatible and biodegradable iron oxide incorporated chitosan-gelatin bioglass composite nanoparticles [Fe-BG]. The developed composite nanoparticle was analyzed by X-ray diffraction (XRD), transmission electron microscopy (TEM), Fourier transform infrared (FTIR) spectroscopy, thermo gravimetric analysis (TG) and differential scanning calorimetry analysis (DSC). The size of the negatively charged composite nanoparticle was in the range of 43-51 nm. The in vitro analysis of the composite nanoparticles was carried out by cell aggregation, protein adsorption and haemolytic activity. The magnetic hysteresis value of the composite nanoparticle showed that it is a soft magnetic material. The presence of iron oxide in the chitosan-gelatin bioglass [BG] matrix enhances biodegradability as indicated in the TG studies. Iron-oxide in equal amount to bioglass in the polymer matrix has been obtained as the optimized system. The developed composite nanoparticle is a soft magnetic material and is suitable for the magnetic hyperthermia treatment and drug delivery. More detailed in vivo studies are needed to confirm the biodegradation profile and biological activity of the material.
本研究专注于开发一种具有生物相容性和可生物降解性的氧化铁结合壳聚糖-明胶生物玻璃复合纳米粒子 [Fe-BG]。通过 X 射线衍射 (XRD)、透射电子显微镜 (TEM)、傅里叶变换红外 (FTIR) 光谱、热重分析 (TG) 和差示扫描量热法分析 (DSC) 对所开发的复合纳米粒子进行了分析。带负电荷的复合纳米粒子的尺寸在 43-51nm 范围内。通过细胞聚集、蛋白质吸附和溶血活性对复合纳米粒子进行了体外分析。复合纳米粒子的磁滞值表明它是一种软磁材料。在 TG 研究中表明，氧化铁在壳聚糖-明胶生物玻璃 [BG] 基质中的存在增强了生物降解性。在聚合物基质中，铁氧化物的含量与生物玻璃相等，已获得优化系统。所开发的复合纳米粒子是一种软磁材料，适用于磁热疗和药物输送。需要进行更详细的体内研究来确认材料的生物降解特性和生物活性。
