[早产儿血清S100B蛋白水平与脑损伤的关系]
[Relationship between serum S100B protein level and brain damage in preterm infants].
作者信息
Xie Li-Juan, Li Hua-Jun, Zhu Jian-Xing
机构信息
Department of Pediatrics, Xinhua Hospital of Shanghai Jiaotong University School of Medicine, Shanghai 200092, China.
出版信息
Zhongguo Dang Dai Er Ke Za Zhi. 2012 Jul;14(7):485-8.
OBJECTIVE
To study changes of serum S100B protein level in preterm infants with brain damage and its role.
METHODS
Forty-seven preterm infants were classified into 3 groups based on the results of brain ultrasound and MRI: brain white matter damage (WMD; n=13), brain but not white matter damage (non-WMD; n=14) and control (no brain damage; n=20). Blood samples were collected within 24 hrs, 72 hrs and 7 days after birth. S100B protein level was measured using ELISA.
RESULTS
Serum levels of S100B in the WMD and non-WMD groups were significantly higher than in the control group within 24 hours, 72 hours and 7 days after birth (P<0.05). More increased serum S100B levels were observed in the WMD group compared with the non-WMD group (P<0.05).
CONCLUSIONS
Serum S100B protein level increases in preterm infants with brain damage within 7 days after birth, suggesting that it may be used as an early sensitive marker for the diagnosis of brain damage, especially WMD.
目的
研究脑损伤早产儿血清S100B蛋白水平的变化及其作用。
方法
根据脑超声和磁共振成像结果，将47例早产儿分为3组：脑白质损伤（WMD；n = 13）、脑损伤但无白质损伤（非WMD；n = 14）和对照组（无脑损伤；n = 20）。于出生后24小时、72小时和7天采集血样。采用酶联免疫吸附测定法检测S100B蛋白水平。
结果
出生后24小时、72小时和7天，WMD组和非WMD组的血清S100B水平显著高于对照组（P < 0.05）。与非WMD组相比，WMD组血清S100B水平升高更明显（P < 0.05）。
结论
出生后7天内，脑损伤早产儿血清S100B蛋白水平升高，提示其可能作为脑损伤尤其是WMD诊断的早期敏感标志物。
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