• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

醋酸亮丙瑞林水剂激发试验在女童中的药效动力学：临床诊断与黄体生成素峰值时间的相关性。

Pharmacodynamics of aqueous leuprolide acetate stimulation testing in girls: correlation between clinical diagnosis and time of peak luteinizing hormone level.

机构信息

Department of Pediatric Endocrinology, Baylor College of Medicine, Houston, TX, USA.

出版信息

J Pediatr. 2012 Oct;161(4):757-9.e1. doi: 10.1016/j.jpeds.2012.06.015. Epub 2012 Jul 17.

DOI:10.1016/j.jpeds.2012.06.015
PMID:22809662
Abstract

We assessed the pharmacodynamics of a 3-hour leuprolide stimulation test in 11 girls with precocious puberty to determine an optimal single sampling time. Luteinizing hormone level following leuprolide stimulation was near maximum by 30 minutes in girls with central precocious puberty, whereas it continued to rise slowly in girls with nonprogressive puberty.

摘要

我们评估了 11 例性早熟女孩的 3 小时促黄体生成素释放激素刺激试验的药效动力学，以确定最佳的单次采样时间。中枢性性早熟女孩的促黄体生成素水平在 30 分钟时已接近最大，而在非进展性青春期女孩中则继续缓慢升高。

相似文献

1
Pharmacodynamics of aqueous leuprolide acetate stimulation testing in girls: correlation between clinical diagnosis and time of peak luteinizing hormone level.醋酸亮丙瑞林水剂激发试验在女童中的药效动力学：临床诊断与黄体生成素峰值时间的相关性。
J Pediatr. 2012 Oct;161(4):757-9.e1. doi: 10.1016/j.jpeds.2012.06.015. Epub 2012 Jul 17.
2
Effects of leuprolide in the treatment of central precocious puberty.亮丙瑞林治疗中枢性性早熟的疗效
J Pediatr. 1989 Feb;114(2):321-4. doi: 10.1016/s0022-3476(89)80806-6.
3
Leuprolide stimulation testing for the evaluation of early female sexual maturation.促黄体生成素刺激试验在评估女性早期性成熟中的应用。
Clin Endocrinol (Oxf). 2010 Sep;73(3):375-81. doi: 10.1111/j.1365-2265.2010.03796.x. Epub 2010 Feb 23.
4
A single luteinizing hormone determination 2 hours after depot leuprolide is useful for therapy monitoring of gonadotropin-dependent precocious puberty in girls.在长效醋酸亮丙瑞林注射2小时后进行单次促黄体生成素测定，有助于监测女童促性腺激素依赖性性早熟的治疗情况。
J Clin Endocrinol Metab. 2004 Sep;89(9):4338-42. doi: 10.1210/jc.2003-031537.
5
The diagnostic value of a brief GnRH analogue stimulation test in girls with central precocious puberty: a single 30-minute post-stimulation LH sample is adequate.简短促性腺激素释放激素类似物刺激试验对中枢性性早熟女童的诊断价值：单次刺激后30分钟的促黄体生成素样本就足够了。
J Pediatr Endocrinol Metab. 2008 Dec;21(12):1113-8. doi: 10.1515/jpem.2008.21.12.1113.
6
Adequacy of a single unstimulated luteinizing hormone level to diagnose central precocious puberty in girls.单次非刺激状态下促黄体生成素水平对诊断女童中枢性性早熟的充足性。
Pediatrics. 2009 Jun;123(6):e1059-63. doi: 10.1542/peds.2008-1180.
7
Suppression of gonadotropin secretion by a long-acting gonadotropin-releasing hormone analog (leuprolide acetate, Lupron Depot) in children with precocious puberty.长效促性腺激素释放激素类似物（醋酸亮丙瑞林，抑那通）对性早熟儿童促性腺激素分泌的抑制作用。
J Clin Endocrinol Metab. 1989 Nov;69(5):1087-9. doi: 10.1210/jcem-69-5-1087.
8
Basal luteinizing hormone/follicle stimulating hormone ratio in diagnosis of central precocious puberty.基础促黄体生成素/促卵泡生成素比值在中枢性性早熟诊断中的应用
J Med Assoc Thai. 2003 Jun;86 Suppl 2:S145-51.
9
Gonadotropin and Estradiol Levels after Leuprolide Stimulation Tests in Brazilian Girls with Precocious Puberty.巴西性早熟女孩使用亮丙瑞林刺激试验后的促性腺激素和雌二醇水平。
J Pediatr Adolesc Gynecol. 2015 Oct;28(5):313-6. doi: 10.1016/j.jpag.2014.09.006. Epub 2014 Sep 23.
10
The usefulness of the leuprolide stimulation test as a diagnostic method of idiopathic central precocious puberty in girls.亮丙瑞林刺激试验作为女孩特发性中枢性性早熟诊断方法的实用性。
Horm Metab Res. 2014 Dec;46(13):959-63. doi: 10.1055/s-0034-1387790. Epub 2014 Oct 8.

引用本文的文献

1
Sensitivity and specificity of using pelvic ultrasonographic parameters combined with basal gonadotropin levels to diagnose central precocious puberty in Thai girls.泰国女孩中使用盆腔超声参数联合基础促性腺激素水平诊断中枢性性早熟的敏感性和特异性。
Asian Biomed (Res Rev News). 2021 Feb 21;15(1):27-34. doi: 10.2478/abm-2021-0004. eCollection 2021 Feb.
2
Clinical risk score for central precocious puberty among girls with precocious pubertal development: a cross sectional study.临床风险评分在具有性早熟发育的女孩中的中枢性性早熟：一项横断面研究。
BMC Endocr Disord. 2021 Apr 20;21(1):75. doi: 10.1186/s12902-021-00740-7.
3
Pathological and Incidental Findings in 403 Taiwanese Girls With Central Precocious Puberty at Initial Diagnosis.
403 例台湾中枢性性早熟女童初诊时的病变及偶发发现。
Front Endocrinol (Lausanne). 2020 May 5;11:256. doi: 10.3389/fendo.2020.00256. eCollection 2020.
4
Evaluation of puberty by verifying spontaneous and stimulated gonadotropin values in girls.通过检测女孩自发性和刺激性促性腺激素值来评估青春期。
J Pediatr Endocrinol Metab. 2015 Mar;28(3-4):387-92. doi: 10.1515/jpem-2014-0135.
5
Random unstimulated pediatric luteinizing hormone levels are not reliable in the assessment of pubertal suppression during histrelin implant therapy.在组氨瑞林植入治疗期间，随机未刺激状态下的儿童促黄体生成素水平在评估青春期抑制方面并不可靠。
Int J Pediatr Endocrinol. 2013 Dec 2;2013(1):20. doi: 10.1186/1687-9856-2013-20.