Lee P A, Page J G
Children's Hospital, Pittsburgh, PA 15213.
J Pediatr. 1989 Feb;114(2):321-4. doi: 10.1016/s0022-3476(89)80806-6.
Leuprolide acetate (D-Leu6 des-Gly-NH2(10), Pro-ethylamide9), a synthetic non-apeptide analog of naturally occurring gonadotropin releasing hormone, was used to treat 62 children with central precocious puberty. Sex steroid levels (testosterone in boys and estradiol in girls) were suppressed during treatment lasting from 3.5 to 24.9 months. Basal follicle-stimulating hormone values and both luteinizing hormone and follicle-stimulating hormone peak responses to stimulation by luteinizing hormone releasing hormone were also suppressed, although basal luteinizing hormone values did not differ. Linear growth rate and the rate of bone age advancement decreased during leuprolide therapy. Side effects were minimal. The long-term safety of this treatment has not yet been established; however, leuprolide appears to be an effective long-term therapy for central precocious puberty.
醋酸亮丙瑞林（D-亮氨酸6 去甘氨酸-NH2(10)，脯氨酸-乙酰胺9），一种天然促性腺激素释放激素的合成九肽类似物，被用于治疗62例中枢性性早熟儿童。在持续3.5至24.9个月的治疗期间，性类固醇水平（男孩的睾酮和女孩的雌二醇）受到抑制。基础促卵泡激素值以及促黄体生成素和促卵泡激素对促黄体生成素释放激素刺激的峰值反应也受到抑制，尽管基础促黄体生成素值没有差异。在亮丙瑞林治疗期间，线性生长速率和骨龄进展速率降低。副作用极小。这种治疗的长期安全性尚未确立；然而，亮丙瑞林似乎是中枢性性早熟的一种有效的长期治疗方法。
