无线快速循环伏安法监测深部脑刺激期间特发性震颤患者的腺苷。
Wireless fast-scan cyclic voltammetry to monitor adenosine in patients with essential tremor during deep brain stimulation.
机构信息
Department of Neurologic Surgery, Mayo Clinic, Rochester, MN 55905, USA.
出版信息
Mayo Clin Proc. 2012 Aug;87(8):760-5. doi: 10.1016/j.mayocp.2012.05.006. Epub 2012 Jul 16.
Abstract
Essential tremor is often markedly reduced during deep brain stimulation simply by implanting the stimulating electrode before activating neurostimulation. Referred to as the microthalamotomy effect, the mechanisms of this unexpected consequence are thought to be related to microlesioning targeted brain tissue, that is, a microscopic version of tissue ablation in thalamotomy. An alternate possibility is that implanting the electrode induces immediate neurochemical release. Herein, we report the experiment performing with real-time fast-scan cyclic voltammetry to quantify neurotransmitter concentrations in human subjects with essential tremor during deep brain stimulation. The results show that the microthalamotomy effect is accompanied by local neurochemical changes, including adenosine release.
摘要
特发性震颤在深部脑刺激时通过在激活神经刺激前植入刺激电极可显著减轻。这种被称为微丘脑切开术效应的现象，其机制被认为与靶向脑组织的微损伤有关，即丘脑切开术中的组织消融的微观版本。另一种可能性是，植入电极会诱导即时神经化学物质释放。在此，我们报告了使用实时快速扫描循环伏安法在特发性震颤患者进行的实验，以量化深部脑刺激期间的神经递质浓度。结果表明，微丘脑切开术效应伴随着局部神经化学变化，包括腺苷的释放。
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