Department of Psychiatry and Behavioral Sciences and Department of Pharmacology, University of Washington, Seattle, Washington, USA.
Nat Methods. 2010 Feb;7(2):126-9. doi: 10.1038/nmeth.1412. Epub 2009 Dec 27.
Neurotransmission operates on a millisecond timescale but is changed by normal experience or neuropathology over days to months. Despite the importance of long-term neurotransmitter dynamics, no technique exists to track these changes in a subject from day to day over extended periods of time. Here we describe and characterize a microsensor that can detect the neurotransmitter dopamine with subsecond temporal resolution over months in vivo in rats and mice.
神经传递在毫秒时间尺度上运作，但在数天到数月的时间内，会因正常的经验或神经病理学而发生变化。尽管长期神经递质动力学很重要，但目前还没有技术可以在长时间内每天跟踪受试者的这些变化。在这里，我们描述并表征了一种微传感器，它可以在大鼠和小鼠体内以亚秒级的时间分辨率在数月内检测神经递质多巴胺。
