Department of Clinical Biochemistry, Dışkapı Yıldırım Beyazıt Training and Research Hospital, Ankara, Turkey.
Inflamm Res. 2012 Nov;61(11):1241-6. doi: 10.1007/s00011-012-0521-z. Epub 2012 Jul 19.
BACKGROUND/AIMS: To determine serum vitronectin levels in Behçet patients with and without ocular involvement, and to evaluate the relationship between vitronectin concentrations and clinical manifestations of Behçet's disease (BD).
Sixty-five patients with BD and 21 control subjects were included. All patients were queried for the clinical manifestations of BD. Serum vitronectin concentrations were determined by using in vitro enzyme immunoassay kits.
Serum vitronectin levels between the patients and the control subjects were not different. There was no statistically significant difference between vitronectin levels in Behçet patients with and without ocular involvement. No correlation was found between vitronectin concentrations and clinical manifestations.
This is the first study evaluating vitronectin levels in Behçet patients. Further studies involving larger numbers of subjects would be useful to improve our understanding of the functions of vitronectin in BD.
背景/目的：测定伴有或不伴有眼部受累的白塞病患者血清中 vitronectin 的水平，并评估 vitronectin 浓度与白塞病（BD）临床表现之间的关系。
纳入 65 例 BD 患者和 21 例对照者。所有患者均被询问 BD 的临床表现。采用体外酶免疫试剂盒测定血清 vitronectin 浓度。
患者与对照组之间血清 vitronectin 水平无差异。伴有或不伴有眼部受累的白塞病患者之间 vitronectin 水平无统计学差异。vitronectin 浓度与临床表现之间无相关性。
这是首次评估白塞病患者 vitronectin 水平的研究。进一步的研究涉及更多的对象将有助于提高我们对白塞病中 vitronectin 功能的理解。
