Logan J L, Benson B
Department of Internal Medicine, University of Arizona, Tucson.
Prostaglandins Leukot Essent Fatty Acids. 1990 Nov;41(3):183-6. doi: 10.1016/0952-3278(90)90088-3.
Compensatory growth of the kidney occurs in response to a partial reduction in renal mass. This compensatory renal growth may be regulated by a circulating renotropic factor. Prostaglandin synthesis has been shown to be increased in kidneys undergoing compensatory renal growth in vivo. In the present study we observed that the addition of rabbit sera obtained after uninephrectomy enhanced DNA synthesis in primary cultures of rabbit kidney cells compared to sera obtained prenephrectomy. The stimulated kidney cells produced more prostaglandin E2 than control cells. Furthermore, the addition of prostaglandin E2 to rabbit kidney cells in the presence of control sera also stimulated DNA synthesis. These results provide further evidence that prostaglandins may participate in the biological events which regulate renal growth in response to a circulating renotropic factor.
肾脏的代偿性生长是对肾实质部分减少的一种反应。这种肾脏的代偿性生长可能受一种循环促肾生长因子的调节。在体内进行代偿性肾脏生长的肾脏中，前列腺素合成已被证明会增加。在本研究中，我们观察到，与肾切除术前获得的血清相比，单肾切除术后获得的兔血清添加到兔肾细胞原代培养物中可增强DNA合成。受刺激的肾细胞比对照细胞产生更多的前列腺素E2。此外，在对照血清存在的情况下，向兔肾细胞中添加前列腺素E2也刺激了DNA合成。这些结果进一步证明，前列腺素可能参与了响应循环促肾生长因子调节肾脏生长的生物学过程。
