[一种来自麦冬的新型C27甾体糖苷硫酸盐]

[A novel C27-steroidal glycoside sulfate from Liriope graminifolia].

作者信息

Wang Kui-Wu, Ju Xian-Yan, Zhang Lei, Wang Wei, Shen Lian-Qing

机构信息

School of Food Science and Biotechnology, Zhejiang Gongshang University, Hangzhou 310035, China.

出版信息

Yao Xue Xue Bao. 2012 May;47(5):619-23.

PMID:22812006

Abstract

An unusual novel C27-steroidal glycoside sulfate was isolated from the underground organs of Liriope graminifolia (Linn.) Baker with three known compounds. Their chemical structures were determined by spectral analysis, including HR-MS, 1D and 2D NMR as (25S)-ruscogenin 1-sulfate-3-O-alpha-L-rhamnopyranoside (1), (25S)-ruscogenin 1-O-beta-D-xylopyranosyl-3-O-alpha-L-rhamnopyranoside (2), hesperidin (3), and 4', 7-dihydroxy-5-methoxyflavanone (4). Compound 1 has cytotoxic activities against K562 and HL60 cells with IC50 values of 18.6 microg x mL(-1) and 16.5 microg x mL(-1), respectively.

摘要

从麦冬（Liriope graminifolia (Linn.) Baker）的地下器官中分离出一种不同寻常的新型C27甾体糖苷硫酸盐以及三种已知化合物。通过光谱分析，包括高分辨质谱（HR-MS）、一维和二维核磁共振（NMR）确定了它们的化学结构，分别为(25S)-鲁斯可皂苷元1-硫酸酯-3-O-α-L-鼠李吡喃糖苷（1）、(25S)-鲁斯可皂苷元1-O-β-D-木糖吡喃糖基-3-O-α-L-鼠李吡喃糖苷（2）、橙皮苷（3）和4',7-二羟基-5-甲氧基黄烷酮（4）。化合物1对K562和HL60细胞具有细胞毒性活性，IC50值分别为18.6 μg·mL-1和16.5 μg·mL-1。