Tang Liying, Wang Zhuju, Wu Hongwei, Yokosuka Akihito, Mimaki Yoshihiro
Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, No.16 Nanxiaojie, Dongzhimennei, Beijing 100700, China; Department of Medicinal Pharmacognosy, School of Pharmacy, Tokyo University of Pharmacy and Life Sciences, 1432-1 Horinouchi, Hachioji, Tokyo 192-0392, Japan.
Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, No.16 Nanxiaojie, Dongzhimennei, Beijing 100700, China.
Phytochemistry. 2014 Nov;107:102-10. doi: 10.1016/j.phytochem.2014.07.021. Epub 2014 Aug 21.
Six spirostanol glycosides (1-6) and 12 known compounds (7-18) were isolated from the underground parts of Dracaena thalioides (Agavaceae). Their structures were determined by spectroscopic analysis, including 2D NMR spectroscopic data, and chemical transformations. The isolated compounds were evaluated for cytotoxic activity against HL-60 human leukemia cells. Compounds 1, 3-6, and 8-18 showed cytotoxicity against HL-60 cells, of which 10, a bisdesmosidic spirostanol derivative, showed potent cytotoxicity against HL-60 cells with an IC50 value of 0.38μM and induced apoptosis in HL-60 cells.
从小花龙血树（龙舌兰科）的地下部分分离得到了6个螺甾烷醇糖苷（1 - 6）和12个已知化合物（7 - 18）。通过光谱分析，包括二维核磁共振光谱数据和化学转化确定了它们的结构。对分离得到的化合物进行了针对HL - 60人白血病细胞的细胞毒性活性评估。化合物1、3 - 6以及8 - 18对HL - 60细胞显示出细胞毒性，其中双糖链螺甾烷醇衍生物10对HL - 60细胞表现出强细胞毒性，IC50值为0.38μM，并诱导HL - 60细胞凋亡。
