Breskina T N, Demidova A B, Konoshenok G V, Chinilina I V
Ter Arkh. 1990;62(9):64-7.
Hypertonic crises were treated in 42 patients with the aid of depin-E, a new drug belonging to the nifedipine group. There were 35 patients with essential hypertension and 7 with secondary arterial hypertension. The initial drug dose was 10 mn (1 capsule) given sublingually. If necessary the drug was indicated again after 20 minutes, the dose being the same. The hypotensive treatment turned out to be highly effective in 37 patients (80%). Of these, 18 patients manifested the drug efficacy after intake of 10 mg, 19 after intake of 20 mg of the drug. In contrast to other nifedipines, depin-E is marked by rapid hypotensive action, pronounced diuretic effect and good tolerance. The hypotensive effect of the drug determined by primarily peripheral vasodilatation did not depend on the types of the central hemodynamics.
42例高渗性危象患者借助属于硝苯地平类的新药depin-E进行治疗。其中35例为原发性高血压患者，7例为继发性动脉高血压患者。初始药物剂量为舌下含服10毫克（1粒胶囊）。如有必要，20分钟后可再次给药，剂量相同。降压治疗在37例患者（80%）中显示出高效。其中，18例患者在服用10毫克药物后显示出药效，19例在服用20毫克药物后显示出药效。与其他硝苯地平类药物不同，depin-E的特点是降压作用迅速、利尿作用显著且耐受性良好。该药物通过主要的外周血管扩张所产生的降压作用不依赖于中心血流动力学类型。
