Orlov V A, Zavolovskaia L I, Zamotaev I P, Venediktova M G, Sokolova V I
Klin Med (Mosk). 1990 Jun;68(6):85-8.
Acute course and long-term regimens of depin-E administration were evaluated clinically and pharmacologically in 50 patients with chronic obstructive bronchitis (COB) and chronic cor pulmonale (CCP). The drug has three mechanisms of action: arteriolovenodilating, bronchodilating, direct pulmonary vascular. Therapeutic effect was achieved in 80% and 60% of COB and CCP patients, respectively. No response was demonstrated for patients with severe cardiac failure. Depin-E can be recommended for prophylaxis and treatment of CCP, to arrest hypertension crises in lesser circulation, to improve pulmonary circulation, central hemodynamics, exercise tolerance.
对50例慢性阻塞性支气管炎（COB）和慢性肺源性心脏病（CCP）患者进行了Depin-E急性疗程和长期治疗方案的临床及药理学评估。该药物有三种作用机制：小动脉和静脉舒张、支气管舒张、直接作用于肺血管。COB和CCP患者的治疗有效率分别为80%和60%。重度心力衰竭患者未显示出疗效。Depin-E可推荐用于CCP的预防和治疗，用于控制微循环中的高血压危象，改善肺循环、中心血流动力学和运动耐量。
