Department of Chemistry, University of North Carolina, Chapel Hill, NC 27599, USA.
Lab Chip. 2012 Sep 7;12(17):3036-9. doi: 10.1039/c2lc40330g. Epub 2012 Jul 20.
The trapping of air bubbles presents a substantial impediment for the user in the increasingly widespread use of lab-on-a-chip products having microcavities in the forms of microwells, traps, dead ends and corners. Here we demonstrate a simple, effective, and passive method to eliminate air bubbles by coating hydrophilized microarray and microfluidic devices with a monosaccharide such as D-glucose or D-sorbitol, where the microcavities are filled with a conformal, elliptical, cone-shaped monosaccharide solid. These devices were stored in air for up to 6 months with a complete rewetting of the microcavities by dissolution of the monosaccharide with an aqueous solution.
气泡的捕获给使用者带来了很大的阻碍，这使得越来越多的微流控芯片产品得到了广泛的应用，这些产品的微腔形式有微孔、陷穴、死腔和拐角等。在这里，我们展示了一种简单、有效且被动的方法，通过用单糖（如 D-葡萄糖或 D-山梨醇）对亲水微阵列和微流控器件进行涂层，来消除气泡。在这些微腔中填充了单糖的共形、椭圆形、锥形固体。这些器件在空气中储存长达 6 个月，通过单糖在水溶液中的溶解，微腔可以完全重新润湿。
