Nederbragt H, Vos J H, van Niel M H, Misdorp W
Vakgroep Veterinaire Pathologie, Faculteit Diergeneeskunde, Rijksuniversiteit Utrecht.
Tijdschr Diergeneeskd. 1990 Oct 15;115(20):948-57.
The essence of the cell-matrix interaction in tissues is that cells influence the composition of the extracellular matrix but that, on the other hand, components of the matrix are also involved in the regulation of growth and differentiation of the cells. Interaction is also found to occur in tumours though in a different way, so that infiltration and metastasis and the occurrence of scirrhous carcinomas are the result. Canine and feline mammary tumours are interesting objects for the study of this interaction since fibroadenomatous changes, in which connective tissue is the predominating tissue, is a common finding in cats only, whereas mixed and complex mammary tumours, producing matrix components of varying type, are common tumours in dogs.
组织中细胞与基质相互作用的本质在于，细胞影响细胞外基质的组成，但另一方面，基质成分也参与细胞生长和分化的调节。在肿瘤中也发现了相互作用，不过方式不同，浸润、转移以及硬癌的发生就是这种相互作用的结果。犬猫乳腺肿瘤是研究这种相互作用的有趣对象，因为纤维腺瘤样改变（其中结缔组织是主要组织）仅在猫中常见，而产生不同类型基质成分的混合性和复杂性乳腺肿瘤是犬的常见肿瘤。
