Institute for Molecules and Materials, Radboud University Nijmegen, The Netherlands.
Org Biomol Chem. 2012 Sep 7;10(33):6767-75. doi: 10.1039/c2ob25662b. Epub 2012 Jul 19.
A series of novel glycine esters was evaluated for efficiency in subtilisin A-CLEA-catalysed peptide synthesis. The reactivity of the easily accessible carboxyamidomethyl (Cam) ester was further enhanced by elongating it with an amino acid residue, thereby creating more recognition space for subtilisin A.
一系列新型甘氨酸酯被评估用于枯草杆菌蛋白酶 A-CLEA 催化的肽合成中的效率。通过用氨基酸残基延长其长度，进一步增强了易于获得的羧甲酰胺基（Cam）酯的反应性，从而为枯草杆菌蛋白酶 A 创造了更多的识别空间。
