碱性蛋白酶催化肽酯的非对映选择性水解。无消旋肽的制备。
Diastereoselective hydrolysis of peptide esters by alkaline protease. Preparation of racemization-free peptides.
作者信息
Chen S T, Wu S H, Wang K T
机构信息
Graduate Institute of Biochemical Sciences, National Taiwan University.
出版信息
Int J Pept Protein Res. 1991 Apr;37(4):347-50. doi: 10.1111/j.1399-3011.1991.tb00749.x.
Abstract
A new and practical enzymatic procedure for preparative diastereoselective hydrolysis of peptide esters using the alkaline protease alcalase as a catalyst was developed. This procedure has been successfully applied to the resolution of peptide diastereomers and synthesis of racemization free peptides.
摘要
开发了一种新的实用酶促方法，以碱性蛋白酶alcalase作为催化剂，用于制备性非对映选择性水解肽酯。该方法已成功应用于肽非对映异构体的拆分和无消旋肽的合成。
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