Polsinelli Gina N, Levitan Robert N, De Luca Vincenzo
Department of Psychiatry, Centre for Addiction and Mental Health, University of Toronto, Toronto, Ontario, Canada.
Psychiatr Genet. 2012 Oct;22(5):219-25. doi: 10.1097/YPG.0b013e32835669b3.
Several lines of research have found that genes in the serotonergic system may cause susceptibility to eating disorders (EDs). In particular, functional polymorphisms of the serotonin transporter gene (5-HTT) have been suspected to play a role in the pathogenesis of eating disorders. Several studies have examined the association between the 5-HTTLPR polymorphism and bulimia nervosa (BN). The results of these investigations have been unclear. The aims of this meta-analysis were to clarify the association between BN and 5-HTTLPR using statistical models not used by previous meta-analyses, and extend upon previous meta-analyses by including new samples. PsychINFO, ISI, and PubMed databases were searched for studies published up to May 2011. Ultimately, six case-control samples were included. Data were pooled using dominant and additive models. Both models showed a nonsignificant association between the 5-HTTLPR polymorphism and BN. However, this does not detract from recent research suggesting that the 5-HTTLPR polymorphism may be responsible for the phenotypic variability in the psychopathological symptoms observed in patients with BN. Future research should examine the association of BN with 5-HTTLPR using the recently proposed triallelic model.
多项研究发现，血清素能系统中的基因可能导致饮食失调（EDs）易感性。特别是，血清素转运体基因（5-HTT）的功能多态性被怀疑在饮食失调的发病机制中起作用。多项研究探讨了5-HTTLPR多态性与神经性贪食症（BN）之间的关联。这些研究结果尚不清楚。本荟萃分析的目的是使用先前荟萃分析未使用的统计模型来阐明BN与5-HTTLPR之间的关联，并通过纳入新样本扩展先前的荟萃分析。检索了PsychINFO、ISI和PubMed数据库中截至2011年5月发表的研究。最终，纳入了六个病例对照样本。使用显性模型和加性模型汇总数据。两种模型均显示5-HTTLPR多态性与BN之间无显著关联。然而，这并不影响最近的研究，该研究表明5-HTTLPR多态性可能是BN患者观察到的精神病理症状表型变异的原因。未来的研究应使用最近提出的三等位基因模型来研究BN与5-HTTLPR的关联。
