Institute of Psychiatry, University of Bologna, Italy.
Int J Eat Disord. 2011 Apr;44(3):191-9. doi: 10.1002/eat.20811.
Eating disorders are influenced by both environmental factors and genes. The 5-HTTLPR polymorphism of serotonin transporter gene has been suggested as a good candidate. This meta-analysis was undertaken: (1) to investigate the association between 5-HTTLPR and eating disorders considered as a whole, including anorexia (AN), bulimia (BN), and binge eating disorder (BED); (2) to extend recently reported findings on the association between 5-HTTLPR and AN-BN.
PubMed, ISI, and PsycINFO databases were searched for studies published until October 2009. Fifteen studies have been included. Data were analyzed with the Cochrane Collaboration Review Manager Software. Quality of studies and publication bias were assessed.
An association between S allele and eating disorders, in particular AN, has been found.
To be carrier of the 5-HTTLPR S allele seem to represent a risk factor for eating disorders, especially for AN. However, considering the reported high between-study heterogeneity, future studies should focus on more homogeneous endophenotype.
饮食失调受环境因素和基因的影响。5-羟色胺转运体基因的 5-HTTLPR 多态性被认为是一个很好的候选基因。本荟萃分析旨在：（1）探讨 5-HTTLPR 与饮食失调的整体相关性，包括厌食症（AN）、贪食症（BN）和暴食障碍（BED）；（2）扩展最近报道的 5-HTTLPR 与 AN-BN 相关性的发现。
检索了截至 2009 年 10 月的 PubMed、ISI 和 PsycINFO 数据库中的研究。共纳入了 15 项研究。使用 Cochrane 协作 Review Manager 软件分析数据。评估了研究的质量和发表偏倚。
发现 S 等位基因与饮食失调，特别是 AN 之间存在关联。
携带 5-HTTLPR S 等位基因似乎是饮食失调的一个危险因素，特别是 AN。然而，考虑到报道的研究间异质性较高，未来的研究应集中在更同质的表型上。
