Biological Sciences Division, Pacific Northwest National Laboratory, Richland, WA 99352, USA.
Bioinformatics. 2012 Sep 15;28(18):2404-6. doi: 10.1093/bioinformatics/bts449. Epub 2012 Jul 19.
The size and complex nature of mass spectrometry-based proteomics datasets motivate development of specialized software for statistical data analysis and exploration. We present DanteR, a graphical R package that features extensive statistical and diagnostic functions for quantitative proteomics data analysis, including normalization, imputation, hypothesis testing, interactive visualization and peptide-to-protein rollup. More importantly, users can easily extend the existing functionality by including their own algorithms under the Add-On tab.
DanteR and its associated user guide are available for download free of charge at http://omics.pnl.gov/software/. We have an updated binary source for the DanteR package up on our website together with a vignettes document. For Windows, a single click automatically installs DanteR along with the R programming environment. For Linux and Mac OS X, users must install R and then follow instructions on the DanteR website for package installation.
基于质谱的蛋白质组学数据集的规模和复杂性质促使开发专门的软件来进行统计数据分析和探索。我们介绍了 DanteR,这是一个图形化的 R 包,具有广泛的统计和诊断功能,用于定量蛋白质组学数据分析,包括归一化、插补、假设检验、交互式可视化和肽到蛋白质的汇总。更重要的是,用户可以通过在“附加组件”选项卡下包含自己的算法来轻松扩展现有功能。
DanteR 及其相关用户指南可在 http://omics.pnl.gov/software/ 免费下载。我们在网站上提供了 DanteR 的更新二进制源以及一个简介文档。对于 Windows,只需单击一下即可自动安装 DanteR 以及 R 编程环境。对于 Linux 和 Mac OS X,用户必须安装 R,然后按照 DanteR 网站上的说明进行软件包安装。