Yi Gwang, Jee Byung Chul, Suh Chang Suk, Kim Seok Hyun
Department of Obstetrics and Gynecology, Seoul National University Bundang Hospital, Seongnam, Korea.
Clin Exp Reprod Med. 2012 Jun;39(2):68-72. doi: 10.5653/cerm.2012.39.2.68. Epub 2012 Jun 30.
To investigate the value of stimulated intrauterine insemination (IUI) in women with unilateral tubal occlusion.
Superovulation and IUI was performed during 2003-2010 and the medical records were reviewed retrospectively. Thirty-seven infertile women (52 cycles) with unilateral tubal occlusion diagnosed by hysterosalpingography and without other causes of infertility were selected. One-hundred fourteen patients with unexplained infertility served as a control group (182 cycles). The main outcome was the clinical pregnancy rate per cycle.
The pregnancy rate per cycle was similar, 17.3% for the unilateral tubal occlusion group and 16.5% for the unexplained infertility group. The rate of miscarriage (11.1% vs. 23.3%) and ectopic pregnancy (11.1% vs. 6.7%) was similar between the two groups. The pregnancy rate was higher in patients with proximal occlusion (25.0%) compared with distal occlusion (13.9%) or unexplained infertility, but not statistically significant.
Stimulated IUI can be suggested as the initial treatment option in women with unilateral proximal or distal tubal occlusion.
探讨刺激子宫内人工授精（IUI）在单侧输卵管阻塞女性中的应用价值。
回顾性分析2003年至2010年期间进行超排卵及IUI的病历资料。选取37例经子宫输卵管造影诊断为单侧输卵管阻塞且无其他不孕原因的不孕女性（52个周期）。114例不明原因不孕患者作为对照组（182个周期）。主要观察指标为每个周期的临床妊娠率。
每个周期的妊娠率相似，单侧输卵管阻塞组为17.3%，不明原因不孕组为16.5%。两组的流产率（11.1%对23.3%）和异位妊娠率（11.1%对6.7%）相似。近端阻塞患者的妊娠率（25.0%）高于远端阻塞患者（13.9%）或不明原因不孕患者，但差异无统计学意义。
对于单侧近端或远端输卵管阻塞的女性，可建议将刺激IUI作为初始治疗选择。
