不同类型不稳定动脉粥样硬化斑块中炎症过程的活性

Activity of the inflammatory process in different types of unstable atherosclerotic plaques.

作者信息

Ragino Yu I, Chernyavski A M, Polonskaya Ya V, Volkov A M, Kashtanova E V

机构信息

Institute of Therapy, Siberian Division of the Russian Academy of Medical Sciences, Novosibirsk, Russia.

出版信息

Bull Exp Biol Med. 2012 Jun;153(2):186-9. doi: 10.1007/s10517-012-1672-1.

DOI:10.1007/s10517-012-1672-1

PMID:22816079

Abstract

Inflammatory biomarkers and chemoattractants characteristic and important for different types (lipid; inflammatory erosive; degenerative necrotic) of unstable plaques in coronary arteries were identified and studied in male patients with coronary atherosclerosis without acute coronary syndrome we studied. Among the three types of unstable plaques, elevated concentrations of IL-1β, IL-6, IL-8, IL-18 and monocyte chemotactic protein-1 were characteristic of not only inflammatory erosive type, but also lipid type compared with degenerative necrotic type. Thus, intensification of the inflammatory process plays an important role in the development of not only inflammatory and destructive, but also of lipid type of unstable atherosclerotic plaques.

摘要

在我们研究的无急性冠状动脉综合征的男性冠状动脉粥样硬化患者中，识别并研究了对冠状动脉中不同类型（脂质型、炎症糜烂型、退行性坏死型）不稳定斑块具有特征性且重要的炎症生物标志物和趋化因子。在这三种类型的不稳定斑块中，与退行性坏死型相比，白细胞介素-1β、白细胞介素-6、白细胞介素-8、白细胞介素-18和单核细胞趋化蛋白-1浓度升高不仅是炎症糜烂型斑块的特征，也是脂质型斑块的特征。因此，炎症过程的强化不仅在炎症性和破坏性不稳定动脉粥样硬化斑块的发展中起重要作用，在脂质型不稳定动脉粥样硬化斑块的发展中也起重要作用。