Chereshnev V A, Gankovskaya L V, Koval'chuk L V, Chereshneva M V, Gankovskaya O A, Gavrilova T V
Institute of Immunology and Physiology, Ural Division of the Russian Academy of Sciences, Ekaterinburg, Russia.
Bull Exp Biol Med. 2012 Jun;153(2):236-9. doi: 10.1007/s10517-012-1685-9.
The dynamics of gene expression of two proteins, TLR9 (one of the key receptors recognizing CpG repeats of herpes virus DNA) and β-defensin 2 (antibacterial peptide), was studied on the model of herpetic keratitis in C57Bl/6 and BALB/c mice. New data on differences in TLR9 gene expression in mice of the two strains infected with the virus were obtained. Reduced TLR9 gene expression in the cornea of C57Bl/6 mice was associated with their high sensitivity to infection caused by herpes simplex 1 virus.
在C57Bl/6和BALB/c小鼠的疱疹性角膜炎模型上，研究了两种蛋白质（Toll样受体9（识别疱疹病毒DNA的CpG重复序列的关键受体之一）和β-防御素2（抗菌肽））的基因表达动态。获得了关于两种感染该病毒的小鼠品系中TLR9基因表达差异的新数据。C57Bl/6小鼠角膜中TLR9基因表达降低与它们对单纯疱疹病毒1型感染的高敏感性有关。
