耻垢分枝杆菌紫霉素抗性突变体中30 S核糖体组分间的相互作用

Interaction between 30 S ribosomal components in a viomycin resistant mutant of Mycobacterium smegmatis.

作者信息

Mizuguchi Y, Suga K, Yamada T

出版信息

Microbiol Immunol. 1979;23(7):595-604. doi: 10.1111/j.1348-0421.1979.tb00500.x.

DOI:10.1111/j.1348-0421.1979.tb00500.x

Abstract

A high level viomycin resistant mutant of Mycobacterium smegmatis ATCC 14468 (AC16) was analyzed genetically and biochemically in an attempt to understand the mechanisms of expression of high level viomycin resistance and co-resistance to kanamycin and streptomycin. Genetic analysis has shown that at least three different genes (vicC, str, and kan) were involved in the phenotypic expression of drug resistance in AC16, and high level resistance to viomycin was due to interactions between the products of these genes.

摘要

对耻垢分枝杆菌ATCC 14468（AC16）的一株高水平紫霉素抗性突变体进行了遗传和生化分析，以试图了解高水平紫霉素抗性以及对卡那霉素和链霉素的共抗性的表达机制。遗传分析表明，至少有三个不同的基因（vicC、str和kan）参与了AC16中耐药性的表型表达，而对紫霉素的高水平抗性是由于这些基因产物之间的相互作用。

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