College of Human and Health Sciences, Swansea University, Swansea, Wales, UK.
J Eur Acad Dermatol Venereol. 2013 Apr;27(4):411-8. doi: 10.1111/j.1468-3083.2012.04650.x. Epub 2012 Jul 23.
This paper discusses the role of molecular oxygen as an aid to wound healing, and the potential value of the three major therapies which allow the delivery of oxygen to the wound site: Hyperbaric Oxygen Therapy (HBOT), Topical Oxygen Therapy (TOT) and a new sterile wound dressing, Oxyzyme™. We summarize studies which have been undertaken using these interventions, and discuss their reported effect on chronic, non-healing wounds, in particular, on ulcers associated with Diabetes. The main conclusions drawn from the studies reviewed indicate that therapeutic oxygen can be used as an aid to the healing of chronic wounds; and benefits are clearly evident with the use of both HBOT and TOT. There is also potential for the use of a new, portable, topical oxygen delivery system, oxyzyme. However its use is still embryonic and studies on its effectiveness are limited. More robust measures of its efficacy are urgently needed.
本文探讨了分子氧在伤口愈合中的辅助作用，以及三种主要治疗方法的潜在价值，这三种方法可以将氧气输送到伤口部位：高压氧疗法（HBOT）、局部氧疗法（TOT）和一种新的无菌伤口敷料 Oxyzyme™。我们总结了使用这些干预措施进行的研究，并讨论了它们对慢性、不愈合伤口，特别是与糖尿病相关的溃疡的报告效果。从回顾的研究中得出的主要结论表明，治疗性氧气可作为慢性伤口愈合的辅助手段；HBOT 和 TOT 的使用都明显有益。新型便携式局部氧气输送系统 oxyzyme 的使用也具有潜力。然而，它的应用仍处于起步阶段，其有效性的研究有限。迫切需要更有力的措施来衡量其疗效。
