Xiao Yun, Ahadian Samad, Radisic Milica
1 Department of Chemical Engineering and Applied Chemistry, University of Toronto , Toronto, Ontario, Canada .
2 Institute of Biomaterials and Biomedical Engineering, University of Toronto , Toronto, Ontario, Canada .
Tissue Eng Part B Rev. 2017 Feb;23(1):9-26. doi: 10.1089/ten.TEB.2016.0200. Epub 2016 Aug 19.
Progress in biomaterial science and engineering and increasing knowledge in cell biology have enabled us to develop functional biomaterials providing appropriate biochemical and biophysical cues for tissue regeneration applications. Tissue regeneration is particularly important to treat chronic wounds of people with diabetes. Understanding and controlling the cellular microenvironment of the wound tissue are important to improve the wound healing process. In this study, we review different biochemical (e.g., growth factors, peptides, DNA, and RNA) and biophysical (e.g., topographical guidance, pressure, electrical stimulation, and pulsed electromagnetic field) cues providing a functional and instructive acellular matrix to heal diabetic chronic wounds. The biochemical and biophysical signals generally regulate cell-matrix interactions and cell behavior and function inducing the tissue regeneration for chronic wounds. Some technologies and devices have already been developed and used in the clinic employing biochemical and biophysical cues for wound healing applications. These technologies can be integrated with smart biomaterials to deliver therapeutic agents to the wound tissue in a precise and controllable manner. This review provides useful guidance in understanding molecular mechanisms and signals in the healing of diabetic chronic wounds and in designing instructive biomaterials to treat them.
生物材料科学与工程的进展以及细胞生物学知识的不断增加，使我们能够开发出功能性生物材料，为组织再生应用提供适当的生化和生物物理线索。组织再生对于治疗糖尿病患者的慢性伤口尤为重要。了解和控制伤口组织的细胞微环境对于改善伤口愈合过程至关重要。在本研究中，我们综述了不同的生化（如生长因子、肽、DNA和RNA）和生物物理（如地形引导、压力、电刺激和脉冲电磁场）线索，这些线索提供了一种功能性和指导性的无细胞基质来愈合糖尿病慢性伤口。生化和生物物理信号通常调节细胞-基质相互作用以及细胞行为和功能，从而诱导慢性伤口的组织再生。一些技术和设备已经被开发出来并应用于临床，利用生化和生物物理线索进行伤口愈合应用。这些技术可以与智能生物材料相结合，以精确可控的方式将治疗剂递送至伤口组织。本综述为理解糖尿病慢性伤口愈合中的分子机制和信号以及设计用于治疗这些伤口的指导性生物材料提供了有用的指导。
