Wei S L, Gao Z H, He S P, Liu H J
School of Pharmaceutical Sciences, Beijing Medical University.
Yao Xue Xue Bao. 1990;25(4):284-8.
Streptomycin albumin microspheres were prepared by polymeric dispersing agents. Some physical properties including the size, distribution and surface state of the microspheres were determined. The results showed that the diameter of the microspheres ranged from 10 to 30 microns and the content was 20.3 +/- 0.5%. Drug release from the microspheres was performed by a dynamic dialysis system. Tissue distribution of streptomycin albumin microspheres in rats was studied by both fluorescein isothiocyanate and 125I labelled microspheres. The experiments revealed that the major part of the microspheres accumulated in the lung following intravenous injection. The effectiveness and side effects of the streptomycin in the microspheres remain to be determined.
通过聚合物分散剂制备了链霉素白蛋白微球。测定了微球的一些物理性质，包括大小、分布和表面状态。结果表明，微球直径范围为10至30微米，含量为20.3±0.5%。通过动态透析系统进行微球的药物释放。用异硫氰酸荧光素和125I标记的微球研究了链霉素白蛋白微球在大鼠体内的组织分布。实验表明，静脉注射后微球的主要部分积聚在肺部。微球中链霉素的有效性和副作用仍有待确定。
