Zhang Z, Lu B, Shu G, Xie H, Yi Q, He Y, Wang J
Hua Xi Yi Ke Da Xue Xue Bao. 1995 Jun;26(2):167-71.
This paper is reported the technology of lung targeting gelatin microspheres of streptomycin sulphate (SMS). The microspheres were prepared with natural biodegradable gelatin as the load material and castor oil as the oil phase. The experimental conditions were optimized, the mean volume diameter obtained being 9.7 microns and the mean rate of encapsulation 15.69%. The content, shape and size of the microspheres showed no remarkable change after storage at 37 degrees C RH 75% for 3 months. Activation energy of heat decomposition E = 75.86kJ/mol. In vitro, the SMS release rate was found to accord with Higuchi equation with t1/2 = 8.6h. In vivo (rabbits) the gelatin microspheres were proved to be concentrated in the lung.
本文报道了硫酸链霉素肺靶向明胶微球（SMS）的技术。以天然可生物降解的明胶为载体制备微球，蓖麻油为油相。优化了实验条件，得到的平均体积直径为9.7微米，平均包封率为15.69%。微球的含量、形状和大小在37℃、相对湿度75%下储存3个月后无明显变化。热分解活化能E = 75.86kJ/mol。体外实验发现，SMS释放速率符合Higuchi方程，t1/2 = 8.6小时。体内实验（家兔）证明明胶微球在肺中聚集。
