Pulver A E, Brown C H, Wolyniec P, McGrath J, Tam D, Adler L, Carpenter W T, Childs B
Department of Psychiatry and Behavioral Sciences, School of Medicine, Johns Hopkins University, Baltimore, Maryland 21231.
Acta Psychiatr Scand. 1990 Nov;82(5):344-51. doi: 10.1111/j.1600-0447.1990.tb01399.x.
In a family history study of 366 schizophrenic probands and their 1851 first-degree relatives, we found a relationship between age at onset of psychosis in the male probands and the risk for schizophrenia in their relatives. The relatives of male schizophrenic probands whose onset of psychosis occurred when they were younger than 17 years of age had an increased risk of schizophrenia when compared with the relatives of male probands with an age at onset greater than 17. We did not find an association between age at onset of psychosis in the female probands and familial risk. Cox proportional hazards models permitted us to examine the relationship between age at onset of psychosis in the probands and familial risk while controlling for possible confounding effects.
在一项对366名精神分裂症先证者及其1851名一级亲属的家族史研究中，我们发现男性先证者精神病发作年龄与其亲属患精神分裂症的风险之间存在关联。与精神病发作年龄大于17岁的男性先证者的亲属相比，精神病发作年龄小于17岁的男性精神分裂症先证者的亲属患精神分裂症的风险增加。我们未发现女性先证者精神病发作年龄与家族风险之间存在关联。Cox比例风险模型使我们能够在控制可能的混杂效应的同时，研究先证者精神病发作年龄与家族风险之间的关系。
