Gureje O, Bamidele R, Aderibigbe Y A
Department of Psychiatry, University College Hospital, Ibadan, Nigeria.
Br J Psychiatry. 1994 Apr;164(4):481-6. doi: 10.1192/bjp.164.4.481.
Thirty-six consecutively admitted patients with schizophrenia and 20 with mania were studied for the morbid risk of psychosis in their first-degree relatives. Using the family history method of ascertainment, the morbid risk for schizophrenia in the relatives of schizophrenic probands was 4.12% compared with 1.42% in the relatives of manic probands. While this difference was not statistically significant, that between the morbid risk for affective psychoses in the relatives of manic patients (7.81%) was significantly higher than for the relatives of schizophrenic patients (0%).
对36例连续收治的精神分裂症患者和20例躁狂症患者的一级亲属进行了精神病发病风险研究。采用家族史确定方法，精神分裂症先证者亲属中精神分裂症的发病风险为4.12%，而躁狂症先证者亲属中的发病风险为1.42%。虽然这一差异无统计学意义，但躁狂症患者亲属中情感性精神病的发病风险（7.81%）显著高于精神分裂症患者亲属（0%）。
