Bettega G, Schir E
Service de chirurgie plastique et maxillo-faciale, hôpital A.-Michallon, BP 217, 38043 Grenoble cedex, France.
Rev Stomatol Chir Maxillofac. 2012 Sep;113(4):205-11. doi: 10.1016/j.stomax.2012.05.007. Epub 2012 Jul 20.
We evaluated the clinical contribution of platelet concentrates to oral and maxillo-facial surgery.
This bibliographic research was made using the PubMed MeSH database with the following keywords: "platelet rich fibrin" (PRF), "platelet rich plasma" (PRP), "bone", "facial bone", "dental implant", and "blood platelet". The research was made without any date or language limitation since English summaries were available. All summaries were read to evaluate the relevance of the article. Only original articles and case reports were considered. The articles were classified as "in vitro studies", "animal experiments", or "clinical studies". The research was stopped on March 22, 2012.
One hundred and sixty-nine articles were validated after excluding irrelevant articles, reviews, technical notes, and articles without English or French summaries. Seventeen were in vitro studies, 61 animal experiments, and 91 clinical studies. One hundred and ten complete articles were read to complete summary data. The data of in vitro studies univocally supports of using platelet concentrates. The data from animal experiment studies was less consensual and the validity of animal models was contested. The disparity of clinical study designs and the lack of rigorous methodology did not allow clearly determining platelet concentrate benefits for oral and maxillo-facial surgery.
PRF or PRP clinical benefit has not been clearly demonstrated yet. French regulations relative to their use should be clarified.
我们评估了血小板浓缩物在口腔颌面外科中的临床作用。
本文献研究使用PubMed医学主题词数据库，关键词如下：“富血小板纤维蛋白”（PRF）、“富血小板血浆”（PRP）、“骨”、“面骨”、“牙种植体”及“血小板”。由于有英文摘要，该研究无日期或语言限制。阅读所有摘要以评估文章的相关性。仅纳入原创文章和病例报告。文章分为“体外研究”、“动物实验”或“临床研究”。该研究于2012年3月22日结束。
排除无关文章、综述、技术说明以及无英文或法文摘要的文章后，169篇文章通过验证。其中17篇为体外研究，61篇为动物实验，91篇为临床研究。阅读了110篇完整文章以完善摘要数据。体外研究数据一致支持使用血小板浓缩物。动物实验研究数据的共识性较差，动物模型的有效性也存在争议。临床研究设计的差异以及缺乏严谨的方法学，使得无法明确确定血小板浓缩物对口腔颌面外科的益处。
PRF或PRP的临床益处尚未得到明确证实。应阐明法国关于其使用的相关规定。
