Department of Neurosciences, College of Medicine, Medical University of South Carolina, Charleston, SC 29425, USA.
Environ Res. 2012 Aug;117:112-9. doi: 10.1016/j.envres.2012.06.007. Epub 2012 Jul 20.
Exposure to pesticides and agricultural chemicals has been linked to amyotrophic lateral sclerosis (ALS) although findings have been inconsistent. A meta-analysis of studies published through May, 2011 was conducted to investigate the association of pesticide exposure and risk of ALS.
Six peer-reviewed studies that met criteria were included in a meta-analysis of men involving 1,517 ALS deaths from one retrospective cohort study and 589 ALS or motor neuron disease cases from five case-control studies. A random effects model was used to calculate sex-specific pooled odds ratios (ORs).
Evidence was found for an association of exposure to pesticides and risk of ALS in male cases compared to controls (OR=1.88, 95% CI: 1.36-2.61), although the chemical or class of pesticide was not specified by the majority of studies.
This meta-analysis supports the relationship of exposure to pesticides and development of ALS among male cases compared to controls. The weight of evidence links pesticide exposure to ALS; however, additional prospective studies with a target exposure group are necessary to better elucidate the relationship. Future research should focus on more accurate exposure assessment and the use of job exposure matrices.
尽管研究结果并不一致，但接触农药和农用化学品与肌萎缩侧索硬化症（ALS）有关。 对截至 2011 年 5 月发表的研究进行了荟萃分析，以调查农药接触与 ALS 风险之间的关联。
纳入了一项针对男性的荟萃分析，其中包括一项回顾性队列研究中 1517 例 ALS 死亡和五项病例对照研究中 589 例 ALS 或运动神经元疾病病例。 使用随机效应模型计算了特定于性别的合并比值比（OR）。
与对照组相比，暴露于杀虫剂与男性 ALS 病例的风险之间存在关联（OR=1.88，95%CI：1.36-2.61），尽管大多数研究未具体说明接触的农药或农药类别。
这项荟萃分析支持男性 ALS 病例与对照组相比，接触杀虫剂与 ALS 发展之间的关系。大量证据表明接触杀虫剂与 ALS 之间存在联系；但是，需要进行更多针对目标暴露组的前瞻性研究，以更好地阐明这种关系。未来的研究应侧重于更准确的暴露评估和使用职业暴露矩阵。
