Department of Clinical Neurosciences, Carol Davila University of Medicine and Pharmacy, 020021 Bucharest, Romania.
Department of Neurology, Colentina Clinical Hospital, 020125 Bucharest, Romania.
Int J Mol Sci. 2023 Oct 5;24(19):14927. doi: 10.3390/ijms241914927.
Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease, characterized in its typical presentation by a combination of lower and upper motor neuron symptoms, with a progressive course and fatal outcome. Due to increased recognition of the non-motor symptoms, it is currently considered a multisystem disorder with great heterogeneity, regarding genetical, clinical, and neuropathological features. Often underestimated, autonomic signs and symptoms have been described in patients with ALS, and various method analyses have been used to assess autonomic nervous system involvement. The aim of this paper is to offer a narrative literature review on autonomic disturbances in ALS, based on the scarce data available to date.
肌萎缩侧索硬化症（ALS）是一种神经退行性疾病，其典型表现为下运动神经元和上运动神经元症状的组合，具有进行性病程和致命结局。由于对非运动症状的认识不断提高，目前认为该病是一种具有很大异质性的多系统疾病，在遗传、临床和神经病理学特征方面均存在差异。自主症状在 ALS 患者中经常被低估，并且已经使用各种方法分析来评估自主神经系统的受累情况。本文旨在根据目前有限的数据，对 ALS 中的自主障碍进行叙述性文献综述。
