Department of Addiction, ASL CN2, Viale Coppino 46, 12051 Alba (CN), Italy.
Med Hypotheses. 2012 Oct;79(4):504-7. doi: 10.1016/j.mehy.2012.07.002. Epub 2012 Jul 21.
Methoxetamine is a dissociative anaesthetic showing pharmacodynamic similarities with its analogue ketamine, a medication with demonstrated rapid-acting antidepressant effects. Like ketamine and other arylcyclohexylamine compounds, methoxetamine is thought to be both a noncompetitive NMDA receptor antagonist and a dopamine reuptake inhibitor. Furthermore, it acts as an agonist at dopamine D2, serotonin 5HT2, muscarinic cholinergic, sigma-1, opioid mu and k receptors. The hypothesis is that methoxetamine can produce rapid antidepressant effects in patients with resistant and non-resistant unipolar and bipolar depression.
甲氧基胺是一种分离麻醉剂，其药效学与类似物氯胺酮相似，氯胺酮具有快速抗抑郁作用。与氯胺酮和其他芳基环己基胺化合物一样，甲氧基胺被认为既是非竞争性 NMDA 受体拮抗剂，也是多巴胺再摄取抑制剂。此外，它还是多巴胺 D2、5HT2 血清素、毒蕈碱乙酰胆碱能、西格玛-1、阿片 μ 和 k 受体的激动剂。其假设是，甲氧基胺可以在耐药和非耐药的单相和双相抑郁症患者中产生快速的抗抑郁作用。
