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用于豚鼠细胞免疫学和疫苗研究的工具:细胞表面抗原和细胞系的单克隆抗体。

Tools for cellular immunology and vaccine research the in the guinea pig: monoclonal antibodies to cell surface antigens and cell lines.

机构信息

Robert Koch-Institute Berlin, Nordufer 20, 13353 Berlin, Germany.

出版信息

Vaccine. 2012 Aug 31;30(40):5804-11. doi: 10.1016/j.vaccine.2012.07.012. Epub 2012 Jul 20.

Abstract

The use of monoclonal antibodies directed against membrane proteins of leukocytes has greatly contributed to our understanding of the function and development of the immune system. Meanwhile these reagents provide valuable tools in many fields of research, stretching far beyond immunology and hematology. For guinea pigs only a limited number of such reagents have been described, and the information about availability and specificity is scattered over many years and journals. We provide an overview on the monoclonal antibodies produced since the technique was applied first in this species, with a focus on those reagents which have been characterized in more detail, and which should still be available either commercially or directly from the labs that created them.

摘要

针对白细胞膜蛋白的单克隆抗体的应用极大地促进了我们对免疫系统功能和发展的理解。同时,这些试剂在免疫学和血液学以外的许多研究领域提供了有价值的工具。对于豚鼠,只有少数这样的试剂被描述,并且关于可用性和特异性的信息分散在多年和期刊上。我们提供了自该技术首次应用于该物种以来产生的单克隆抗体的概述,重点介绍了那些经过更详细表征的试剂,这些试剂仍然可以通过商业渠道或直接从创建它们的实验室获得。

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